ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Immunology
Volume 11 – 2024 |
doi: 10.3389/fnut.2024.1517186
Provisionally accepted
The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China
The final, formatted version of the article will be published soon.
Background: Global health issues related to obesity are growing. Visceral adipose tissue (VAT) significantly contributes to complications associated with obesity. Reducing adipose tissue accumulation can improves inflammation. However, it’s still unknown how the systemic immune-inflammation index (SII) and VAT area are related.
Methods: With the help of multivariate logistic regression and smooth curve fitting, the relationship between SII and VAT area was explored with data from the 2013 and 2014 National Health and Nutrition Examination Survey (NHANES). Analyzing subgroups and testing for interaction were used to investigate whether the relationship was accurate across demographics.
Results: From 20 to 59 years of age, 3290 individuals were observed to have a positive correlation between SII and VAT area. In accordance with the fully adjusted model, the VAT area increased by 9.34 cm2 for every unit increase in log SII [β = 9.34, 95% CI (4.02, 14.67)]. In the highest quartile of SII, the VAT area was 5.46 cm2 [β = 5.46, 95% CI (2.21, 8.71)] higher than that in the lowest quartile. Additionally, the population that was overweight or obese showed a stronger positive correlation.
Conclusions: SII has a positive correlation with VAT area in US adults. SII may be valuable in clinical applications to evaluate the severity of VAT area.
Keywords:
systemic immune-inflammation index, visceral adipose tissue area, Obesity, Crosssectional study, NHANES
Received:
25 Oct 2024;
Accepted:
30 Dec 2024.
Copyright:
© 2024 Liao, Zhou, Lin, Deng, Weng and Pan. This is an
open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,
provided the original author(s) or licensor are credited and that the
original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which
does not comply with these terms.
* Correspondence:
Liya Pan, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China
Disclaimer:
All claims expressed in this article are solely those of the authors and
do not necessarily represent those of their affiliated organizations, or
those of the publisher, the editors and the reviewers. Any product that
may be evaluated in this article or claim that may be made by its
manufacturer is not guaranteed or endorsed by the publisher.
